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Volidus
Voglibose INN
Description:
Volidus is a preparation of Voglibose, an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus and in patients with impaired glucose tolerance (IGT).
Volidus is a preparation of Voglibose, an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus and in patients with impaired glucose tolerance (IGT).
Indications:
Voglibose is used in diabetes mellitus (DM) for reduction in Post-Prandial Hyperglycaemia (PPHG), only when diet and/or exercise with lifestyle modification or Oral Hypoglycaemic Agents (OHAs) or insulin preparations, in addition to diet and/or exercise, do not result in an adequate glycaemic control. Thus, Voglibose is indicated:
Voglibose is used in diabetes mellitus (DM) for reduction in Post-Prandial Hyperglycaemia (PPHG), only when diet and/or exercise with lifestyle modification or Oral Hypoglycaemic Agents (OHAs) or insulin preparations, in addition to diet and/or exercise, do not result in an adequate glycaemic control. Thus, Voglibose is indicated:
- In non-insulin-dependent diabetes mellitus (NIDDM) patients as immunotherapy
- In combination with other OHAs
- In addition to insulin in diabetes mellitus patients
- In prevention of onset of type 2 diabetes mellitus in impaired glucose tolerance (only for Voglibose INN 0.2 mg Tablets) (However, Volidus Tablets should be used only when impaired glucose tolerance has not been improved in patients already undergoing appropriate dietary treatment and/or exercise therapy.)
- In elderly patients and in those with hepatic dysfunction or mild to moderate renal impairments in whom other OHAs are contraindicated or they need to be used with caution, Voglibose will be helpful.
- In glycogen storage disease: Voglibose is helpful in prevention of hypoglycaemia in patients with type lb glycogen storage disease, it being an amylase (a glucosidase) inhibitor.
- In non-diabetic Hyperinsulinemia, Voglibose is helpful in preventing hypoglycaemic attacks.
- In steroid induced diabetes mellitus also, Voglibose is helpful. However, clinical data in this setting are limited.
Mode of Action:
Voglibose is an alpha-glycosidase inhibitor. Alpha glucosidase inhibitor delays the glucose absorption at the intestine level and prevents sudden increase of glucose after meal. The drug exerts its anti-hyperglycemic action by producing reversible competitive inhibition of alpha-glucosidase hydrolase enzyme which is the final enzyme in the carbohydrate digestion in the brush border of small intestinal mucosa.
Voglibose is an alpha-glycosidase inhibitor. Alpha glucosidase inhibitor delays the glucose absorption at the intestine level and prevents sudden increase of glucose after meal. The drug exerts its anti-hyperglycemic action by producing reversible competitive inhibition of alpha-glucosidase hydrolase enzyme which is the final enzyme in the carbohydrate digestion in the brush border of small intestinal mucosa.
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