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Metryl IV
Metronidazole
Description:
Metronidazole IV (Metryl IV) infusion is a sterile, pyrogen free, isotonic, ready to use solution requiring no dilution or buffering prior to intravenous administration in susceptible life threatening infections. Metronidazole is a 5-nitroimidazole derivative that has extremely broad spectrum activity against protozoa & anaerobic bacteria. It is active against a wide range of pathogenic micro-organisms notably species of Bacteroides, Fusobacteria, Clostridia, Eubacteria, Anaerobic cocci, Gardnerella lamblia, Balantidium coli and the causative organisms of acute ulcerative gingivitis.
Metronidazole IV (Metryl IV) infusion is a sterile, pyrogen free, isotonic, ready to use solution requiring no dilution or buffering prior to intravenous administration in susceptible life threatening infections. Metronidazole is a 5-nitroimidazole derivative that has extremely broad spectrum activity against protozoa & anaerobic bacteria. It is active against a wide range of pathogenic micro-organisms notably species of Bacteroides, Fusobacteria, Clostridia, Eubacteria, Anaerobic cocci, Gardnerella lamblia, Balantidium coli and the causative organisms of acute ulcerative gingivitis.
Indications:
It is indicated in
It is indicated in
- The prevention of Post-operative infections due to anaerobic bacteria, particularly species of bacteroides and anaerobic Streptococci in case of intraabdomianl infections, gynaecologial and obstetrical infections, respiratory infections etc.
- The treatment of septicaemia, bacteremia, peritonitis, brain abscess, necrotising, pneumonia, osteomyeitis, puerperal sepsis, pelvic abscess, pelvic cellulites, and post-operative wound infections from which pathogenic anaerobes have been isolated.
- Urogenital trichomoniasis in the female (trichomonal vaginitis) and in the male.
- Bacterial vaginosis (also known as non specific vaginitis, anaerobic vaginosis or Gardnerella vaginitis).
- All forms of amebiasis (intestinal and extra-intestinal disease and that of symptomless cyst passers).
- Giardiasis
- Acute ulcerative gingivitis.
- Anaerobically infected leg ulcers and pressure sores.
- Acute dental infections (e.g. acute pericoronitis and acute apical infections).
Mode of Action:
Metronidazole is converted to reactive metabolites by the redox enzyme pyruvate-ferredoxin oxidoreductase. Here, the nitro group of metronidazole is chemically reduced by ferredoxin (or a ferredoxin-linked metabolic process) to a reactive intermediate which causes the loss of helical structure of DNA, strand breakage and impairment of DNA function. So, nucleic acid synthesis is inhibited. Thus, causes the cell death of Bacteria.
Metronidazole is converted to reactive metabolites by the redox enzyme pyruvate-ferredoxin oxidoreductase. Here, the nitro group of metronidazole is chemically reduced by ferredoxin (or a ferredoxin-linked metabolic process) to a reactive intermediate which causes the loss of helical structure of DNA, strand breakage and impairment of DNA function. So, nucleic acid synthesis is inhibited. Thus, causes the cell death of Bacteria.
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