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Editoren
Cefditoren
Description:
Cefditoren (Editoren) is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity for oral administration. It is a prodrug which is hydrolyzed by esterases during absorption, and the drug is distributed in the circulating blood as active Cefditoren.
Cefditoren (Editoren) is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity for oral administration. It is a prodrug which is hydrolyzed by esterases during absorption, and the drug is distributed in the circulating blood as active Cefditoren.
Indications:
Editoren is indicated for the treatment of infections in adults and adolescents (12 years of age or older) which are caused by susceptible microorganisms:
Editoren is indicated for the treatment of infections in adults and adolescents (12 years of age or older) which are caused by susceptible microorganisms:
- Acute Bacterial Exacerbation of Chronic Bronchitis caused by Haemophilus influenzae (including ß-lactamase-producing strains)
- Haemophilus parainfluenzae (including ß-lactamase producing strains), Streptococcus pneumoniae, or Moraxella catarrhalis (including ß-lactamase-producing strains).
- Community-Acquired Pneumonia caused by Haemophilus influenzae (including ß-lactamase-producing strains), Haemophilus parainfluenzae (including ß-lactamase-producing strains), Streptococcus pneumoniae or Moraxella catarrhalis (including ß-lactamase producing strains).
- Pharyngitis/Tonsillitis caused by Streptococcus pyogenes and eradication of Streptococcus pyogenes from the oropharynx.
- Uncomplicated Skin and Skin-Structure Infections caused by Staphylococcus aureus (including ß-lactamase-producing strains) or Streptococcus pyogenes.
Mode of Action:
Cefditoren (Editoren) inactivates penicillin binding proteins (PBPs) thereby interfering with peptidoglycan synthesis and inhibiting bacterial cell wall synthesis. Another consequence of beta-lactam exposure results in the loss of lipoteichoic acids from the cell wall. Lipoteichoic acids inhibit murein hydrolase activity and their absence from the cell wall triggers uncontrolled autolytic activity rendering bacterial cells susceptible to osmotic shock. This results in a reduction of cell wall stability and causes celllysis.
Cefditoren (Editoren) inactivates penicillin binding proteins (PBPs) thereby interfering with peptidoglycan synthesis and inhibiting bacterial cell wall synthesis. Another consequence of beta-lactam exposure results in the loss of lipoteichoic acids from the cell wall. Lipoteichoic acids inhibit murein hydrolase activity and their absence from the cell wall triggers uncontrolled autolytic activity rendering bacterial cells susceptible to osmotic shock. This results in a reduction of cell wall stability and causes celllysis.
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