Description:
Encarlev is a combination of Levodopa, Entacapone and Carbidopa which is used to treat Parkinson's disease. Parkinson's disease is a disorder of the central nervous system (brain and spinal cord). Dopamine is a naturally occurring substance in the brain that helps to provide control of movement and activities such as walking and talking. In patients with Parkinson's disease, there is not enough dopamine in some parts of the brain. Levodopa (a component of this medicine) enters the brain and helps to replace the missing dopamine, which allows people to function better. By increasing the amount of dopamine in the brain, Levodopa helps to control symptoms and helps to perform daily activities such as dressing, walking, and handling utensils.

Indications:
Encarlev is indicated for the treatment of adult patients with Parkinson's disease and end-of-dose motor fluctuations not stabilized on Levodopa/Carbidopa treatment.

Mode of Action:
Levodopa works by being converted to dopamine in the brain. Carbidopa is in a class of medications called decarboxylase inhibitors. It works by preventing Levodopa from being broken down before it reaches the brain. This allows for a lower dose of Levodopa, which causes less nausea and vomiting. The mechanism of action of Entacapone is believed to be through its ability to inhibit Catechol-O-Methyltransferase (COMT) in peripheral tissues, altering the plasma pharmacokinetics of Levodopa.

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