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Xelnib
Tofacitinib INN
Description:
Tofacitinib is a Janus Kinase (JAK) inhibitor used in the treatment of moderate to severe active rheumatoid arthritis.
Tofacitinib is a Janus Kinase (JAK) inhibitor used in the treatment of moderate to severe active rheumatoid arthritis.
Indications:
Tofacitinib is indicated for the treatment of adult patients with moderate to severe active rheumatoid arthritis who have an inadequate response or intolerance to Methotrexate. It may be used as monotherapy or in combination with Methotrexate or other nonbiologic disease-modifying antirheumatic drugs (DMARDs).
Tofacitinib is indicated for the treatment of adult patients with moderate to severe active rheumatoid arthritis who have an inadequate response or intolerance to Methotrexate. It may be used as monotherapy or in combination with Methotrexate or other nonbiologic disease-modifying antirheumatic drugs (DMARDs).
Mode of Action:
It is an inhibitor of Janus Kinase (JAK). JAKs are intracellular enzymes which transmit signals arising from cytokine or growth factor-receptor interactions on the cellular membrane to influence cellular processes of hematopoiesis and immune cell function. Tofacitinib modulates the signaling pathway of cytokine at the point of JAKs, preventing the phosphorylation and activation of Signal Transducers and Activators of Transcription (STATs) which inhibits gene expression and cytokine production.
It is an inhibitor of Janus Kinase (JAK). JAKs are intracellular enzymes which transmit signals arising from cytokine or growth factor-receptor interactions on the cellular membrane to influence cellular processes of hematopoiesis and immune cell function. Tofacitinib modulates the signaling pathway of cytokine at the point of JAKs, preventing the phosphorylation and activation of Signal Transducers and Activators of Transcription (STATs) which inhibits gene expression and cytokine production.
Different Dosages from Xelnib
Other Brands From Same Therapeutic Class
