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Febuxit
Febuxostat INN
Description:
Febuxostat is a xanthine oxidase inhibitor. It is a non-hygroscopic, white crystalline powder.
Febuxostat is a xanthine oxidase inhibitor. It is a non-hygroscopic, white crystalline powder.
Indications:
Febuxit® is indicated for the chronic management of hyperuricemia in patients with gout.
Febuxit® is not recommended for the treatment of asymptomatic hyperuricemia.
Febuxit® is indicated for the chronic management of hyperuricemia in patients with gout.
Febuxit® is not recommended for the treatment of asymptomatic hyperuricemia.
Mode of Action:
Febuxit® (Febuxostat) decreases serum uric acid level by inhibiting xanthine oxidase, an enzyme responsible for the production of uric acid. The absorption of Febuxostat following oral dose administration was estimated to be at least 49%. Maximum plasma concentrations of Febuxostat occurred between 1 to 1.5 hours post-dose. After multiple oral 40 mg and 80 mg once daily doses, Cmax is approximately 1.6 +- 0.6 mcg per mL and 2.6 +- 1.7 mcg per mL, respectively. The plasma protein binding of Febuxostat is approximately 99.2%, (primarily to albumin). The apparent mean terminal elimination half-life (t1/2) of Febuxostat is approximately 5 to 8 hours.
Febuxit® (Febuxostat) decreases serum uric acid level by inhibiting xanthine oxidase, an enzyme responsible for the production of uric acid. The absorption of Febuxostat following oral dose administration was estimated to be at least 49%. Maximum plasma concentrations of Febuxostat occurred between 1 to 1.5 hours post-dose. After multiple oral 40 mg and 80 mg once daily doses, Cmax is approximately 1.6 +- 0.6 mcg per mL and 2.6 +- 1.7 mcg per mL, respectively. The plasma protein binding of Febuxostat is approximately 99.2%, (primarily to albumin). The apparent mean terminal elimination half-life (t1/2) of Febuxostat is approximately 5 to 8 hours.
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