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Met XR
Metformin Hydrochloride
Description:
Metformin Hydrochloride USP (extended-release tablets) is an oral antihyperglycemic drug used in the management of Type 2 diabetes. After administration, fluid from the gastrointestinal (GI) tract enters into the tablet, causing the polymers to hydrate and swell & the drug is released slowly from the dosage form by a process of diffusion.
Metformin Hydrochloride USP (extended-release tablets) is an oral antihyperglycemic drug used in the management of Type 2 diabetes. After administration, fluid from the gastrointestinal (GI) tract enters into the tablet, causing the polymers to hydrate and swell & the drug is released slowly from the dosage form by a process of diffusion.
Indications:
Non insulin dependent (Type 2) diabetes mellitus (NIDDM).
Non insulin dependent (Type 2) diabetes mellitus (NIDDM).
Mode of Action:
Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with Type 2 diabetes, lowering both basal and postprandial plasma glucose. Its pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Unlike Sulfonylureas, Metformin does not produce hypoglycemia in either patients with Type 2 diabetes or normal subjects and does not cause hyperinsulinemia.
Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with Type 2 diabetes, lowering both basal and postprandial plasma glucose. Its pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Unlike Sulfonylureas, Metformin does not produce hypoglycemia in either patients with Type 2 diabetes or normal subjects and does not cause hyperinsulinemia.
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