Description:
Dequa^® VT is the preparation of Dequalinium Chloride which belongs to the family of anti-infective and antiseptic drugs. It is active against the bacteria which cause bacterial vaginosis. Dequa^® VT is inserted into the vagina for treatment at the site of infection

Indications:
Dequa^® VT is indicated for the treatment of bacterial vaginosis.

Mode of Action:
Dequa^® VT has a multiple mode of action. It disrupts the cell permeability of the bacteria by absorbing onto the bacterial cell surface and diffusing across the membrane. It also binds to the cytoplasmic membrane with subsequent formation of complexes and protein precipitation and lyses the membrane in adequate concentrations, perturbing osmotic exchange. Loss of normal enzymatic activity is achieved through several different processes. Denaturation of proteins results in inhibition of bacterial cell metabolism. Disruption of bacterial energy production is mediated through inhibition of glucose metabolism and inhibition of mitochondrial ATP synthesis via inhibition of bacterial F1-ATPase. Protein synthesis is also terminated at the level of ribosomes. Bacterial nucleic acids are also affected through direct binding of the drug to DNA in vitro, and precipitation of cytoplasmic material with nucleic acids being the most sensitive.

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