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Doxorin
Doxophylline INN
Description:
Doxophylline is a xanthine derivative drug used in the treatment of asthma. It has anti-inflammatory & antitussive action in addition to bronchodilatory effect.
Doxophylline is a xanthine derivative drug used in the treatment of asthma. It has anti-inflammatory & antitussive action in addition to bronchodilatory effect.
Indications:
Doxophylline is used for the treatment of Bronchial asthma, COPD and bronchospasm.
Doxophylline is used for the treatment of Bronchial asthma, COPD and bronchospasm.
Mode of Action:
Doxophylline is a novel bronchodilator. It structurally differs from Theophylline due to the presence of a dioxolane group in position 7. Doxophylline selectively inhibits phosphodiesterase-4 thereby relaxes bronchial smooth muscle. However, differently from Theophylline, Doxophylline appears to have decreased affinities toward adenosine A1 and A2 receptors, which may account for the better safety profile of the drug. Doxophylline is reported to inhibit platelet activating factor (PAF) and generation of leukotriene production.
Doxophylline is a novel bronchodilator. It structurally differs from Theophylline due to the presence of a dioxolane group in position 7. Doxophylline selectively inhibits phosphodiesterase-4 thereby relaxes bronchial smooth muscle. However, differently from Theophylline, Doxophylline appears to have decreased affinities toward adenosine A1 and A2 receptors, which may account for the better safety profile of the drug. Doxophylline is reported to inhibit platelet activating factor (PAF) and generation of leukotriene production.
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