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Cildip
Cilnidipine
Description:
Cilnidipine is a 4th generation Calcium Channel Blocker. It is vaso selective and has a weak direct dromotropic effect, a strong vasodepressor effect and an arrhythmia inhibiting effect.
Cilnidipine is a 4th generation Calcium Channel Blocker. It is vaso selective and has a weak direct dromotropic effect, a strong vasodepressor effect and an arrhythmia inhibiting effect.
Indications:
Cildip is indicated for the management of hypertension for end-organ protection. It is reported to be useful in elderly patients and in those with diabetes and albuminuria. Cildip has been increasingly used in patients with chronic kidney disease Hypertension is the term used to describe the presence of high blood pressure. The blood pressure is generated by the force of the blood pumped from the heart against the blood vessels. Thus hypertension is caused when there is too much pressure on the blood vessels and this effect can damage the blood vessel
Cildip is indicated for the management of hypertension for end-organ protection. It is reported to be useful in elderly patients and in those with diabetes and albuminuria. Cildip has been increasingly used in patients with chronic kidney disease Hypertension is the term used to describe the presence of high blood pressure. The blood pressure is generated by the force of the blood pumped from the heart against the blood vessels. Thus hypertension is caused when there is too much pressure on the blood vessels and this effect can damage the blood vessel
Mode of Action:
Cilnidipine is a Ca2+ channel blocker with a dual L & N-type ca2+ channel blocking action. The L-type calcium channel blockade by cilnidipine affects predominantly vascular smooth muscle, thereby producing vasodilation of peripheral resistance vessels and coronary arteries. The blockade of N-type calcium channels effectively suppresses neurohormonal regulation in the cardiovascular system, including sympathetic nervous system and renin-angiotensin-aldosterone system. Thus Cilnidipine can reduce various types of complications of hypertension as well as cardiovascular diseases.
Cilnidipine is a Ca2+ channel blocker with a dual L & N-type ca2+ channel blocking action. The L-type calcium channel blockade by cilnidipine affects predominantly vascular smooth muscle, thereby producing vasodilation of peripheral resistance vessels and coronary arteries. The blockade of N-type calcium channels effectively suppresses neurohormonal regulation in the cardiovascular system, including sympathetic nervous system and renin-angiotensin-aldosterone system. Thus Cilnidipine can reduce various types of complications of hypertension as well as cardiovascular diseases.
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